Effect of normal aging versus hypertension, abnormal body mass index, and diabetes mellitus on white matter hyperintensity volume
BACKGROUND AND PURPOSE: The natural history of white matter hyperintensity (WMH) progression resulting from normal aging versus comorbid vascular insults remains unclear. Therefore we investigated age-related differences in WMH volumes among a group with comorbid hypertension, abnormal body mass index, and diabetes mellitus to a normal aging group drawn from the same population lacking any of these comorbidities. METHODS: WMH volumes were acquired using 3T MRI for 2011 Dallas Heart Study participants. The slope of the WMH versus age regression was compared between normal and comorbidity groups<50 and ≥50 years of age where a change in slope was demonstrated. RESULTS: Aging was linearly associated with greater log WMH volume for both normal (P=0.02) and comorbidity (P<0.0001) groups. Beyond 50 years of age, more rapid increases in WMH volumes for age were seen in the group with comorbidities (P<0.0001) but not in the normal group (P=0.173). The between-group difference in slope of expected WMH for age was significantly greater in the comorbidity groups≥50 years of age (P=0.0008) but not <50 years of age (P=0.752). CONCLUSIONS: After 50 years of age, but not before, comorbid hypertension, obesity, and diabetes mellitus were associated with significantly larger WMH volumes for age compared with a normal aging group lacking these conditions. These results support the assertion that age-related differences in WMH volumes are significantly increased in the presence of comorbidities, but the effect is only detectable after 50 years of age.
Medical Subject Headings
Adult; Age Factors; Aged; Aged, 80 and over; Aging (pathology, physiology); Body Mass Index; Brain (pathology); Comorbidity; Diabetes Mellitus (pathology); Ethnicity; Female; Humans; Hypertension (pathology); Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Middle Aged; Obesity (complications, pathology); Regression Analysis; Risk Factors; Sex Factors; Socioeconomic Factors
Digital Object Identifier (DOI)
King, Kevin S.; Peshock, Ronald M.; Rossetti, Heidi C.; McColl, Roderick W.; Ayers, Colby R.; Hulsey, Keith M.; and Das, Sandeep R., "Effect of normal aging versus hypertension, abnormal body mass index, and diabetes mellitus on white matter hyperintensity volume" (2014). Neuroradiology. 48.