Initial cognitive changes in Parkinson's disease

Document Type

Article

Abstract

The focus on cognitive impairment in neurodegenerative diseases, including PD, is shifting from the dementia stage to earlier stages of impairment, including mild cognitive impairment. This shift is driven primarily by the desire to improve long-term outcomes by delivering therapeutic interventions earlier in the clinical course, even presymptomatically in those at highest risk, and at the initial stage in the pathophysiological cascade that underpins common dementia syndromes. This article focuses on key findings and challenges in studying earliest stages of cognitive decline in PD, including a detailed examination of neuropsychological testing, cognitive performance in early and prodromal PD, epidemiological research for PD mild cognitive impairment to date, and expert recommendations for assessment. © 2018 International Parkinson and Movement Disorder Society.

Publication Date

4-1-2018

Publication Title

Movement Disorders

ISSN

08853185

E-ISSN

15318257

Volume

33

Issue

4

First Page

511

Last Page

519

PubMed ID

29543342

Digital Object Identifier (DOI)

10.1002/mds.27330

Link to Full Text

Share

COinS