Effect and time course of deep brain stimulation of the globus pallidus and subthalamus on motor features of Parkinson's disease
Document Type
Article
Abstract
We studied the effect and temporal profile of deep brain stimulation (DBS) of the globus pallidus and subthalamic nucleus on the motor signs of Parkinson's disease (PD). Four patients with bilateral deep brain stimulators of the globus pallidus and four patients with bilateral deep brain stimulators of the subthalamus were studied while taking no medication and at 15 and 30 minutes and 1, 2, 4, and 6 hours after turning stimulation on. An immediate (15 minutes) and sustained (6 hours) benefit was observed for all the motor manifestations of PD for both stimulation sites. Deep brain stimulation of the globus pallidus and subthalamus is highly effective in reducing all the cardinal motor features of PD.
Publication Date
10-9-2000
Publication Title
Clinical Neuropharmacology
ISSN
03625664
Volume
23
Issue
4
First Page
208
Last Page
211
PubMed ID
11020125
Digital Object Identifier (DOI)
10.1097/00002826-200007000-00007
Recommended Citation
Hristova, Anna; Lyons, Kelly; Tröster, Alexander I.; Pahwa, Rajesh; Wilkinson, Steven B.; and Koller, William C., "Effect and time course of deep brain stimulation of the globus pallidus and subthalamus on motor features of Parkinson's disease" (2000). Clinical Neuropsychology. 68.
https://scholar.barrowneuro.org/neuropsychology/68