Title

Effect and time course of deep brain stimulation of the globus pallidus and subthalamus on motor features of Parkinson's disease

Document Type

Article

Abstract

We studied the effect and temporal profile of deep brain stimulation (DBS) of the globus pallidus and subthalamic nucleus on the motor signs of Parkinson's disease (PD). Four patients with bilateral deep brain stimulators of the globus pallidus and four patients with bilateral deep brain stimulators of the subthalamus were studied while taking no medication and at 15 and 30 minutes and 1, 2, 4, and 6 hours after turning stimulation on. An immediate (15 minutes) and sustained (6 hours) benefit was observed for all the motor manifestations of PD for both stimulation sites. Deep brain stimulation of the globus pallidus and subthalamus is highly effective in reducing all the cardinal motor features of PD.

Publication Date

10-9-2000

Publication Title

Clinical Neuropharmacology

ISSN

03625664

Volume

23

Issue

4

First Page

208

Last Page

211

PubMed ID

11020125

Digital Object Identifier (DOI)

10.1097/00002826-200007000-00007

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