Risk of Parkinson's disease dementia related to level I MDS PD-MCI.
Document Type
Article
Abstract
BACKGROUND: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.
METHODS: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia.
RESULTS: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia.
CONCLUSIONS: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.
Medical Subject Headings
Age Factors; Aged; Cognitive Dysfunction; Dementia; Female; Humans; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Risk Factors; Sex Factors
Publication Date
3-1-2019
Publication Title
Movement disorders : official journal of the Movement Disorder Society
ISSN
1531-8257
Volume
34
Issue
3
First Page
430
Last Page
435
PubMed ID
30653248
Digital Object Identifier (DOI)
10.1002/mds.27617
Recommended Citation
Hoogland, Jeroen; Boel, Judith A; de Bie, Rob M A; Schmand, Ben A; Geskus, Ronald B; Dalrymple-Alford, John C; Marras, Connie; Adler, Charles H; Weintraub, Daniel; Junque, Carmen; Pedersen, Kenn F; Mollenhauer, Brit; Goldman, Jennifer G; Tröster, Alexander I; Burn, David J; Litvan, Irene; and Geurtsen, Gert J, "Risk of Parkinson's disease dementia related to level I MDS PD-MCI." (2019). Clinical Neuropsychology. 279.
https://scholar.barrowneuro.org/neuropsychology/279