Title

Developing a model of chronic subdural hematoma

Document Type

Conference Proceeding

Abstract

Chronic subdural hematoma (CSDH) is a common neurosurgical condition that has a high incidence in the increasing elderly population of many countries. Pathologically, it is defined as a persistent liquefied hematoma in the subdural space more than 3 weeks old that is generally encased by a membraneous capsule. CSDHs likely originate after minor head trauma, with a key factor in its development being the potential for a subdural cavity to permit its expansion within, which is usually due to craniocerebral disproportion. The pathogenesis of CSDH has been attributed to osmotic or oncotic pressure differences, although measurements of these factors in the CSDH fluid do not support this theory. Current belief is that CSDH arises from recurrent bleeding in the subdural space, caused by a cycle of local angiogenesis, inflammation, coagulation and ongoing fibrinolysis. However, because of a lack of detailed knowledge about the precise mechanisms, treatment is often limited to surgical interventions that are invasive and often prone to recurrence. Thus, it is possible that an easily reproducible and representative animal model of CSDH would facilitate research in the pathogenesis of CSDH and aid with development of treatment options. © 2011 Springer-Verlag/Wien.

Publication Date

1-1-2011

Publication Title

Acta Neurochirurgica, Supplementum

ISSN

00651419

E-ISSN

00016268

ISBN

9783709106921

Issue

111

First Page

25

Last Page

29

PubMed ID

21725727

Digital Object Identifier (DOI)

10.1007/978-3-7091-0693-8_5

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