Title

Lack of collagen XVIII/endostatin results in eye abnormalities

Document Type

Article

Abstract

Mice lacking collagen XVIII and its proteolytically derived product endostatin show delayed regression of blood vessels in the vitreous along the surface of the retina after birth and lack of or abnormal outgrowth of retinal vessels. This suggests that collagen XVHI/endostatin is critical for normal blood vessel formation in the eye. All basement membranes in wild-type eyes, except Descemet's membrane, showed immunogold labeling with antibodies against collagen XVIII. Labeling at sites where collagen fibrils in the vitreous are connected with the inner limiting membrane and separation of the vitreal matrix from the inner limiting membrane in mutant mice indicate that collagen XVHI is important for anchoring vitreal collagen fibrils to the inner limiting membrane. The findings provide an explanation for high myopia, vitreoretinal degeneration and retinal detachment seen in patients with Knobloch syndrome caused by loss-of-function mutations in collagen XVIII.

Publication Date

4-2-2002

Publication Title

EMBO Journal

ISSN

02614189

Volume

21

Issue

7

First Page

1535

Last Page

1544

PubMed ID

11927538

Digital Object Identifier (DOI)

10.1093/emboj/21.7.1535

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