Title

Endothelial cell dysfunction in response to intracellular overexpression of amyloid precursor protein

Document Type

Article

Abstract

Previous reports have shown that exposure of vascular endothelial and smooth muscle cells to exogenous amyloid beta (Aβ) peptide results in cell damage and toxicity via oxidative injury. In this study we demonstrate that overexpression of the amyloid precursor protein (APP) is toxic to bovine aortic endothelial cells but not to bovine aortic smooth muscle cells. Intracellular coexpression of the free radical scavenger proteins metallothionein or MnSOD abolished the toxic effect of APP overexpression in endothelial cells. Our results demonstrate that endothelial cells are specifically susceptible to intracellular overexpression of APP and free radical generation is the likely mechanism of cell damage due to APP overexpression.

Publication Date

12-15-1998

Publication Title

Journal of Neuroscience Research

ISSN

03604012

Volume

54

Issue

6

First Page

828

Last Page

839

PubMed ID

9856867

Digital Object Identifier (DOI)

10.1002/(SICI)1097-4547(19981215)54:6<828::AID-JNR11>3.0.CO;2-M

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