Title

Developmentally Regulated Signaling Pathways In Glioma Invasion

Department

neurobiology

Document Type

Article

Abstract

Malignant gliomas are the most common, infiltrative, and lethal primary brain tumors affecting the adult population. The grim prognosis for this disease is due to a combination of the presence of highly invasive tumor cells that escape surgical resection and the presence of a population of therapy-resistant cancer stem cells found within these tumors. Several studies suggest that glioma cells have cleverly hijacked the normal developmental program of neural progenitor cells, including their transcriptional programs, to enhance gliomagenesis. In this review, we summarize the role of developmentally regulated signaling pathways that have been found to facilitate glioma growth and invasion. Furthermore, we discuss how the microenvironment and treatment-induced perturbations of these highly interconnected signaling networks can trigger a shift in cellular phenotype and tumor subtype.

Publication Date

2-1-2018

Publication Title

Cellular and Molecular Life Sciences

ISSN

1420682X

Volume

75

Issue

3

First Page

385

Last Page

402

Digital Object Identifier (DOI)

10.1007/s00018-017-2608-8

This document is currently not available here.

Share

COinS