Association of early experience with neurodegeneration in aged primates
Document Type
Article
Abstract
Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, " standard-sized" cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p< 0.001 and p< 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life. © 2009.
Keywords
β-Amyloid, Aging, Environment, Neocortex, Neurodegeneration, Rhesus monkey, Synapse density, Synaptophysin
Publication Date
1-1-2011
Publication Title
Neurobiology of Aging
ISSN
01974580
Volume
32
Issue
1
First Page
151
Last Page
156
PubMed ID
19321231
Digital Object Identifier (DOI)
10.1016/j.neurobiolaging.2009.01.014
Recommended Citation
Merrill, David A.; Masliah, Eliezer; Roberts, Jeffery A.; McKay, Heather; Kordower, Jeffery H.; Mufson, Elliott J.; and Tuszynski, Mark H., "Association of early experience with neurodegeneration in aged primates" (2011). Translational Neuroscience. 1728.
https://scholar.barrowneuro.org/neurobiology/1728