Title

Association of early experience with neurodegeneration in aged primates

Document Type

Article

Abstract

Environment influences brain development, neurogenesis and, possibly, vulnerability to neurodegenerative disease. We retrospectively examined the brains of aged rhesus monkeys reared during early life in either small cages or larger, " standard-sized" cages; all monkeys were subsequently maintained in standard-sized cages during adulthood. Aged monkeys reared in smaller cages exhibited significantly greater β-amyloid plaque deposition in the neocortex and a significant reduction in synaptophysin immunolabeling in cortical regions compared to aged monkeys reared in standard-sized cages (p< 0.001 and p< 0.05, respectively). These findings suggest that early environment may influence brain structure and vulnerability to neurodegenerative changes in late life. © 2009.

Keywords

β-Amyloid, Aging, Environment, Neocortex, Neurodegeneration, Rhesus monkey, Synapse density, Synaptophysin

Publication Date

1-1-2011

Publication Title

Neurobiology of Aging

ISSN

01974580

Volume

32

Issue

1

First Page

151

Last Page

156

PubMed ID

19321231

Digital Object Identifier (DOI)

10.1016/j.neurobiolaging.2009.01.014

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